New data highlight on the incompatablility of receptors in influenza A transmission
Published: 2024-05-21
The latest data highlight, entitled ‘New study increases understanding of receptor incompatibility in transmission of influenza A virus between species’ is the first related to our influenza topic. As with all data highlights, it showcases research that openly shares data and/or code. In this case, Nilsson et al. (2024) have openly shared mass spectrometry proteomics data in the ProteomeXchange Consortium via the PRIDE partner repository (dataset identifier: PXD036263).
Nilsson et al. (2024), originally published in Glycobiology (DOI: 10.1093/glycob/cwad098), aimed to better understand interspecies transmission of the influenza A virus (IAV). Specifically, they used glycoprotein analysis to investigate linkage conformation of sialic acid-containing glycans, which serve as receptors for IAVs. Nilsson et al. (2024) ultimately showed that complex sialic acid-containing structures were not, as previously thought, specific to mammals. Indeed, they were present in all 3 avian species considered. These results could have major implications for understanding receptor incompatibility and interspecies spread of IAVs, as well as for zoonotic ecology.
To find out more about the study, please read the data highlight. If you are interested in having your work in the areas of pandemic preparedness and/or infectious disease promoted on the portal (e.g. with a data highlight like this one) please contact the portal team.