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COVID-19

Background

COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. COVID-19 was designated as a pandemic in early 2020, and posed a significant challenge for society the world over. Most people suffer mild to moderate respiratory illness following infection, and recover without treatment. However, the disease can be severe or fatal. Severe outcomes are more likely in the elderly, immunocompromised individuals, and those with comorbidities like cancer or diabetes.

Unprecedented levels of collaboration between the research community enabled the route of transmission, and action, of the virus to be understood much more quickly than usual. This reduced the impact of the pandemic. Nevertheless, many lessons can be learned from the pandemic that can help with future pandemic preparedness.

Now, we have entered a more endemic phase, but many research questions remain about COVID-19. For example, there is still uncertainty regarding the duration of vaccine protection and the effectiveness of booster doses. In addition, vaccine escape has been shown by several variants, which could make vaccines less effective.

Data highlights (38)

July 2, 2025
Researchers from Uppsala University Hospital developed and validated two automated workflows within the GUI-based software Geneious Prime 2022.1.1. Validation data and tools are openly available via GitHub, and the Sequence Read Archive.
January 19, 2024
Babačić and colleagues expanded the coverage of the soluble blood proteome using mass spectrometry. In order to support further research in this area, their results have been added to an open-access app.
June 2, 2023
Vaid and Mendez, and collaborators, studied how the gene expression profile of m6A mRNA is affected both during and after COVID-19 infection. All sequencing data and the source code for analysis are shared.

Dashboards (12)

Updated:
The COVID Symptom Study Sweden (CSSS) collects data on COVID-19 prevalence, symptoms, and vaccinations through a smart phone app with over 200.000 users in Sweden. Raw data can be requested for use in research projects.
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A summary of the COVID-19 and SARS-CoV-2 publications produced involving at least one contributor from a Swedish university or research institute. Shows publications over time and key words/phrases within them.
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CRUSH Covid maps outbreaks in Uppsala County by visualising the number of cases, test positivity, and geographic distribution, among other things. Data for each postal code is available for download and reuse.
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A summary of the progress in developing a multi-disease serology assay, a key component of pandemic preparedness. Information about externally produced antigens is also provided.
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The Swedish Board of Health and Welfare (Socialstyrelsen) shares data on Post COVID-19 condition. Here, we show visualisations of data on symptoms, healthcare contacts, and geographic distribution, among other things.
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Dedicated to the work of the register-based large-scale national population study to monitor COVID-19 vaccination effectiveness and safety (RECOVAC) project.
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The national Pandemic Centre (NPC) conducted testing related to SARS-CoV-2 from the start of the pandemic. They show positive, negative, and inconclusive tests. This dashboard is historic, so no longer updated.
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Estimates of SARS-CoV-2 variant frequencies and growth rate advantages from global SARS-CoV-2 genotype sequencing data
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Surveillance of viral genome sequences is crucial in tracking the spread of viral variants. This dashboard shows whole-genome sequencing data generated by Uppsala University Hospital.
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The dashboard displays the SARS-CoV-2 serology tests completed over time at the at SciLifeLab Autoimmunology and Serology Profiling unit. The number of tests in total and the amount of positive/negative tests over time are shown.
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The Swedish Health Agency (Folkhälsomyndigheten) provide data and information related to COVID-19 in Sweden. Visualisations are shown on multiple aspects of vaccination coverage, like coverage in different counties.
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Explore SARS-CoV-2 levels in wastewater across Sweden. Weekly data from SLU-SEEC tracks COVID-19 trends, covering 43% of the population, and aids in outbreak prediction.

Editorials (1)

October 31, 2023
Details the importance of sharing data, tools, and techniques in the COVID-19 pandemic and for future pandemic preparedness. Highlights how this applies to this year’s Nobel Prize in Medicine.
COVID-19

Sample collections (36)

Name Type Size Materials
Dalarna biobank (forskningsprov och nyinsamlade prov):
SARS-CoV-2 PCR positiva Dalarna
Healthcare sample collection 1000 - 10.000 Nasal swab Throat swab
Gävleborg biobank:
Klinisk mikrobiologi
Healthcare sample collection 1000 - 10.000 Nasal swab Serum Throat swab Other
Halland biobank:
Patologen Halland
Healthcare sample collection 100 - 1000 Tissue (stained sections/slides) Tissue (paraffin preserved)

Ongoing research projects (19)

Project title Funder
Mental health of young LGBTQ+ people: Trends over time and during the COVID-19 pandemic, causes of mental ill-health, and ways to improve mental health of young LGBTQ+ people

Host institute: Karolinska Institute
Principal investigator: Kyriaki Kosidou

Forte
The fatigue cohort - A longitudinal study on psychobiological mechanisms in post-COVID, chronic fatigue and exhaustion syndromes.

Host institute: Stockholm University
Principal investigator: Anna Andreasson

Forte
The unequal pandemic: investigating the relationship between health equity and political responses to covid-19

Host institute: Stockholm University
Principal investigator: Karl Gauffin

Forte