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Antibiotic resistance

Background

The introduction of antibiotics revolutionised healthcare. However, over time, microbes developed resistance to them. This has meant that previously treatable diseases now pose a serious threat to public health, and to food security, sustainable development, animal husbandry, veterinary medicine, and research. Antibiotic resistance is a growing problem worldwide. Despite this, it is under-discussed and goes relatively unnoticed by most in society, causing it to be termed a ‘silent pandemic’.

Multiple factors are important in limiting the spread and impact of antibiotic resistance. For example, monitoring is essential to understand the spread, and more research is needed to determine how resistance develops, so that it can be prevented in future. In Sweden, a national liason was established by the government in 2012 to work on the topic of antibiotic resistance (Strama). The collaboration (2021-2025) is a continuation of a previous effort, and is focused on One Health, and is cross-sectorial. You can read more about this effort in publications, such as the guidelines for antibiotic resistance 2021-2025, from the Swedish Public Health Agency. The annual Swedres-Svarm report, co-produced by the Public Health Agency of Sweden (FoHM) and the National Veterinary Institute (SVA), evaluates statistics related to the sale of, and the development of resistance to, antibiotics for both humans and animals.

Novel antibiotics will be needed to treat currently antibiotic-resistant infections. However, the development of novel drugs and effective diagnostic tools is both time consuming and expensive. It is therefore important that this work starts as early as possible. Further, it is essential that policies are put in place to reduce the risk of microbes developing resistance to any new drugs.

Data highlights (1)

April 18, 2023
A study from Elf lab at Uppsala University/SciLifeLab shows perseverance can be a reason for antibiotic resistance development in E. coli. Microscopy image data shared in SciLifeLab Data Repository.

Editorials (1)

September 18, 2024
A thought-piece on how environmental tracking of antimicrobial resistance should be done. It aims to provoke discussion between scientists and stakeholders, particularly in light of upcoming EU legislation.
Infectious Diseases Antibiotic Resistance

Ongoing research projects (18)

Project title Funder
Bacterial Injection Machines within the Human Gut: Structure, Function and Potential as Novel Avenue in Precision Medicine to Battle Antimicrobial Resistance

Host institute: Lund University
Principal investigator: Eva Maria Rebrova (Steiner)

Swedish Research Council
Curing Sepsis - a personalized bench-to bedside approach for prediction and treatment of short and long-term complication in sepsis

Host institute: Lund University
Principal investigator: Adam Linder

Swedish Research Council
DELIVER: An Accelerated Antibiotic Screening Platform

Host institute: Uppsala University
Principal investigator: Anders Karlén

Swedish Research Council